Advantages of Topical Delivery

  • The most significant reason to use topical delivery is that it mimics natural secretion patterns.
  • Topical delivery avoids the first-pass metabolism in the liver and allows a more sustained delivery of hormones.
  • Topical delivery produces therapeutic tissue concentration of hormones at much lower doses. This is true for estrogen, progesterone, testosterone, and DHEA.
  • Only minimal fluctuations in hormone levels occur because the skin acts as a drug reservoir. Systemic levels are maintained more consistently than with oral dosing.

  • * Topical creams can be dosed once to twice daily.

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